Application

Research Sub CategoryRNA Metabolism & Binding Proteins

Research CategoryEpigenetics & Nuclear Function

Anti-MPS-1, clone 4A12 Antibody detects level of MPS-1 & has been published & validated for use in MPS-1.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

40S ribosomal protein S27, also known as Metallopan-stimulin 1 (MPS-1), and encoded by the gene name MPS1 or RPS27, belongs to the ribosomal protein S27e family. Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. MPS-1 is a component of the 40S subunit and contains a C4-type zinc finger domain that can bind to zinc. MPS-1 is located in the cytoplasm as a ribosomal component, but it has also been detected in the nucleus. Studies in rat indicate that MPS-1 is located near ribosomal protein S18 in the 40S subunit and is covalently linked to translation initiation factor eIF3.

Immunogen

Purified recombinant fragment of human MPS-1 expressed in E. Coli

Physical form

Mouse monoclonal IgG1 ascitic fluid containing up to 0.1% sodium azide.

Unpurified

Quality

Immunohistochemistry Analysis: A 1:200-1,000 dilution from a representative lot detected MPS-1 in human lung cancer and brain tissues.

Storage and Stability

Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

Target description

9 kDa calculated